CORONAVIRUSES - COLDS AND SARS
| Auteur: | Microbiology and Immunology on-line University of South Carolina |
| Tags: | Foto's/dia's Lessen/cursussen Leerboek Virussen Hoger onderwijs Middelbaar onderwijs Engels Medisch/Veterinair |
| Bron: | http://pathmicro.med.sc.edu/virol/coronaviruses.htm 
Melding defecte link. |
The viruses that cause about one third of common colds and the newly described severe acute respiratory syndrome Coronaviruses, which are about 100nm in diameter, are the largest positive strand RNA viruses (indeed they have the largest genomes of any RNA virus). They infect humans and animals in which they cause respiratory and enteric disease. The coronaviruses, along with the toroviruses and arteriviruses, belong to a group, the nidovirales, that produce a nested set of mRNA with a common 3’ end (see below). The coronaviruses and the toroviruses (which together make up the Coronaviridae) have helical nucleocapsids while the arteriviruses have icosahedral nucleocapsids. Coronaviruses have an envelope that is derived from intracellular membranes and not the plasma membrane. In electron micrographs they have spikes sticking out of their surfaces (due to a large glycoprotein), leading to their name (corona = crown) (Figure 1 and 2). This chapter will only discuss the Coronaviruses since they are particularly important in human respiratory disease, causing about one third of "common colds" and the newly recognized severe acute respiratory syndrome (SARS).
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