Bacteriophage
| Auteur: | Microbiology and Immunology on-line University of South Carolina |
| Tags: | Medisch/Veterinair Engels Middelbaar onderwijs Hoger onderwijs Bacteriën Virussen Video's Leerboek Lessen/cursussen Foto's/dia's Algemene microbiologie |
| Bron: | http://pathmicro.med.sc.edu/mayer/phage.htm 
Melding defecte link. |
Structure of bacteriophage. The infectious process and the lytic multiplication cycle. The lysogenic cycle and its regulation. A. Definition - Bacteriophage (phage) are obligate intracellular parasites that multiply inside bacteria by making use of some or all of the host biosynthetic machinery (i.e., viruses that infect bacteria.). There are many similarities between bacteriophages and animal cell viruses. Thus, bacteriophage can be viewed as model systems for animal cell viruses. In addition a knowledge of the life cycle of bacteriophage is necessary to understand one of the mechanisms by which bacterial genes can be transferred from one bacterium to another. At one time it was thought that the use of bacteriophage might be an effective way to treat bacterial infections, but it soon became apparent that phage are quickly removed from the body and thus, were of little clinical value. However, bacteriophage are used in the diagnostic laboratory for the identification of pathogenic bacteria (phage typing). Although phage typing is not used in the routine clinical laboratory, it is used in reference laboratories for epidemiological purposes. Recently, new interest has developed in the possible use of bacteriophage for treatment of bacterial infections and in prophylaxis. Whether bacteriophage will be used in clinical medicine remains to be determined. Bacteriophage Phage typing Capsid Tail Contractile sheath Base plate Tail fibers Virulent phage Eclipse Early and late m-RNA Plaque Pfu Lysogeny Temperate phage Prophage Lysogen Cohesive ends Site-specific recombination Repression Induction Lysogenic conversion
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